Diabetes Care 29:2385-2390, 2006
DOI: 10.2337/dc06-1084 © 2006 by the
American Diabetes Association
Clinical Care/Education/Nutrition
Original Article
Does Coffee
Consumption Reduce the Risk of Type 2 Diabetes in Individuals With Impaired
Glucose?
Besa Smith, MPH, Deborah L. Wingard, PHD, Tyler
C. Smith, MS, Donna Kritz-Silverstein, PHD and Elizabeth
Barrett-Connor, MD
From the Division of Epidemiology, Department of Family and
Preventive Medicine, University of California San Diego, La Jolla, California
OBJECTIVEThe purpose of this study was to investigate the
association between coffee
intake and incident diabetes based on an oral glucose tolerance test
(OGTT) and examine coffee
habits in those with impaired glucose separately from those with
normal glucose at baseline.
RESEARCH DESIGN AND METHODSIn this prospective study, 910
adults aged  50
years without diabetes at baseline in 19841987 were followed to
19921996, an average of 8 years after assessment of coffee
intake. Logistic regression models were adjusted for sex, age,
physical activity, BMI, smoking, alcohol, hypertension, and baseline
fasting plasma glucose.
RESULTSPast and current coffee
drinkers had a reduced risk of incident diabetes (odds ratio 0.38
[95% CI 0.170.87] and 0.36 [0.190.68], respectively) compared
with those who never drank coffee.
The 317 participants with baseline impaired glucose who were past or
current coffee
drinkers were also at reduced risk for incident diabetes (0.31
[0.110.87] and 0.36 [0.160.83], respectively).
CONCLUSIONSThis study confirms a striking protective effect
of caffeinated coffee
against incident diabetes and extends these findings to incident
diabetes based on OGTT independent of multiple plausible confounders.
Abbreviations: DBP, diastolic blood pressure
FPG,
fasting plasma glucose OGTT, oral glucose tolerance test PCG,
postchallenge glucose SBP, systolic blood pressure
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